Targeting poly(ADP-ribose) glycohydrolase to draw apoptosis codes in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.004
Abstract: Poly(ADP-ribosyl)ation is a unique post-translational modification of proteins. The metabolism of poly(ADP-ribose) (PAR) is tightly regulated mainly by poly(ADP-ribose) polymerases (PARP) and poly(ADP-ribose) glycohydrolase (PARG). Accumulating evidence has suggested the biological functions of PAR metabolism… read more here.
Keywords: poly adp; dna; cancer; parg ... See more keywords
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Biophysics and Molecular Biology"
DOI: 10.1016/j.pbiomolbio.2021.02.002
Abstract: Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies. Even with effective vaccines, infection… read more here.
Keywords: adp ribose; sars cov; structure; parg ... See more keywords
Kinetics of Macroion Adsorption on Silica: Complementary Theoretical and Experimental Investigations for Poly-l-arginine
Sign Up to like & getrecommendations! Published in 2025 at "Langmuir"
DOI: 10.1021/acs.langmuir.4c03766
Abstract: A comprehensive approach enabling a quantitative interpretation of poly-l-arginine (PARG) adsorption kinetics at solid/electrolyte interfaces was developed. The first step involved all-atom molecular dynamics (MD) modeling of physicochemical characteristics yielding PARG molecule conformations, its contour… read more here.
Keywords: poly arginine; adsorption; macroion adsorption; theoretical experimental ... See more keywords
PARG and BRCA1–BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1153
Abstract: Abstract Meiotic chromosome segregation relies on programmed DNA double-strand break induction. These are in turn repaired by homologous recombination, generating physical attachments between the parental chromosomes called crossovers. A subset of breaks yields recombinant outcomes,… read more here.
Keywords: dna repair; function; pathway choice; parg ... See more keywords
Abstract 6910: Synergistic tumor cell killing with dual inhibition of PARG and USP1
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6910
Abstract: Poly (ADP-ribose) glycohydrolase (PARG) is an enzyme that aid in DNA repair primarily through the removal of poly (ADP-ribose) (PAR) chains from PARylated proteins. PARG inhibitors are currently in clinical development for patients with tumors… read more here.
Keywords: replication; cancer; dual inhibition; parg ... See more keywords
Abstract 6972: Discovery of XNW29016, a PARG inhibitor for HRD cancer therapy
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6972
Abstract: DNA damage repair enzymes are promising targets as genomic instability and DNA repair defects are important characteristics of cancer cells PARylation catalysed by PARP1/2 is a kind of reversible protein modification, which has central functions… read more here.
Keywords: cancer; xnw29016; parylation; repair ... See more keywords
Abstract NT-117: INHIBITION OF PARG, SENSITIZES OVARIAN CANCER CELLS TO PARP INHIBITORS AND DNA DAMAGING AGENTS
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.ovcasymp18-nt-117
Abstract: BACKGROUND: Poly(ADP-ribose) glycohydrolase (PARG) is responsible poly(ADP-ribose) (PAR) catabolism, which is synthesized by poly(ADP-ribose) polymerases (PARPs) at the site of DNA single-strand breaks (SSB). Faulty PAR formation or disintegration inhibits SSB repair. PARP inhibitors (PARPi)… read more here.
Keywords: ovarian cancer; parp inhibitors; cell; parg ... See more keywords
Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13194973
Abstract: Simple Summary We have shown that Clear Cell Renal Cell Carcinoma (ccRCC) is prone to accumulate poly(ADPribose) due to increase in PARP-1 and decrease in PARG enzymes. Reduction of pADPr by PARP-1 inhibition or PARG… read more here.
Keywords: ccrcc; carcinoma; parp; parg ... See more keywords
PARG regulates the proliferation and differentiation of DCs and T cells via PARP/NF-κB in tumour metastases of colon carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2019.7051
Abstract: The present study investigated the effect of poly(ADP-ribose) glycohydrolase (PARG) on the immune response in tumour metastases of colon carcinoma. CT26 cells were transfected with lentivirus PARG-short hairpin RNA (shRNA). A liver metastasis model of… read more here.
Keywords: parg silenced; group; parg; colon carcinoma ... See more keywords