CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.
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DOI: 10.1016/j.kint.2017.09.020
Abstract: A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular… read more here.
Keywords: focal segmental; crescentic glomerulonephritis; parietal epithelial; segmental glomerulosclerosis ... See more keywords
Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease.
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DOI: 10.1681/asn.0000000000000104
Abstract: ABSTRACT Podocytes and parietal epithelial cells (PECs) are among the few principal cell types within the kidney glomerulus, the former serving as a crucial constituent of the kidney filtration barrier and the latter representing a… read more here.
Keywords: cell; interdependence; cell types; disease ... See more keywords
The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy
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DOI: 10.3389/fphys.2022.832772
Abstract: Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of… read more here.
Keywords: role; pathogenesis podocytopathy; parietal epithelial; role parietal ... See more keywords
Differences in Immunohistochemical and Ultrastructural Features between Podocytes and Parietal Epithelial Cells (PECs) Are Observed in Developing, Healthy Postnatal, and Pathologically Changed Human Kidneys
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DOI: 10.3390/ijms23147501
Abstract: During human kidney development, cells of the proximal nephron gradually differentiate into podocytes and parietal epithelial cells (PECs). Podocytes are terminally differentiated cells that play a key role in both normal and pathological kidney function.… read more here.
Keywords: cells pecs; podocytes parietal; microscopy; parietal epithelial ... See more keywords