CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.020
Abstract: A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular… read more here.
Keywords: focal segmental; crescentic glomerulonephritis; parietal epithelial; segmental glomerulosclerosis ... See more keywords
Human parietal epithelial cells as Trojan horses in albumin overload
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DOI: 10.1038/s41598-024-84972-2
Abstract: Parietal Epithelial Cells (PECs) activation and proliferation are common to several distinct forms of glomerulopathies. Due to several stimuli, PECs can change to a progenitor (CD24+ and CD133/2+) or a pro-sclerotic (CD44+) phenotype. In addition,… read more here.
Keywords: cells trojan; parietal epithelial; albumin overload; human parietal ... See more keywords
#2710 Podocyte-specific YAP activation triggers crescentic glomerulonephritis through a crosstalk with parietal epithelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.0200
Abstract: Crescentic glomerulonephritis (cGN) is a severe kidney pathology characterized by the aberrant proliferation of parietal epithelial cells leading to crescent formation within the Bowman's space. Despite its clinical relevance, the molecular pathways involved in crescent… read more here.
Keywords: parietal epithelial; cgn; yap; podocyte ... See more keywords
Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adq7825
Abstract: Crescentic glomerulonephritis (cGN) is a severe kidney pathology characterized by the aberrant proliferation of epithelial cells, leading to crescent formation within the Bowman's space. The molecular pathways involved in crescent formation remain poorly understood despite… read more here.
Keywords: podocyte specific; parietal epithelial; yap; activation ... See more keywords
Revealing the Role of Renin-Angiotensin System Signaling in Parietal Epithelial Cells
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DOI: 10.1152/physiol.2025.40.s1.1569
Abstract: Introduction:. The Bowman's capsule surrounds the kidney's glomerular tuft; it consists of a single layer of parietal epithelial cells (PECs) that serve as a crucial barrier between the urinary space and the renal interstitium. Under… read more here.
Keywords: pecs; parietal epithelial; role; physiology ... See more keywords
Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000000000104
Abstract: ABSTRACT Podocytes and parietal epithelial cells (PECs) are among the few principal cell types within the kidney glomerulus, the former serving as a crucial constituent of the kidney filtration barrier and the latter representing a… read more here.
Keywords: cell; interdependence; cell types; disease ... See more keywords
The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.832772
Abstract: Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of… read more here.
Keywords: role; pathogenesis podocytopathy; parietal epithelial; role parietal ... See more keywords
Differences in Immunohistochemical and Ultrastructural Features between Podocytes and Parietal Epithelial Cells (PECs) Are Observed in Developing, Healthy Postnatal, and Pathologically Changed Human Kidneys
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147501
Abstract: During human kidney development, cells of the proximal nephron gradually differentiate into podocytes and parietal epithelial cells (PECs). Podocytes are terminally differentiated cells that play a key role in both normal and pathological kidney function.… read more here.
Keywords: cells pecs; podocytes parietal; microscopy; parietal epithelial ... See more keywords