PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.02.019
Abstract: Summary PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a… read more here.
Keywords: pten nitrosylation; pi3k akt; activation; park2 ... See more keywords
Reduced expression of PARK2 in manganese‐exposed smelting workers
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.08.006
Abstract: HIGHLIGHTSEffect of Mn exposure on PARK2 gene expression among smelters was studied.Cumulative Mn exposure was significantly higher in smelters than controls.Expression of PARK2 mRNA in smelters was decreased by 42% compared to controls.Expression of PARK2… read more here.
Keywords: park2; reduced expression; expression park2; cumulative exposure ... See more keywords
Second mutation in PARK2 is absent in patients with sporadic Parkinson's disease and heterozygous exonic deletions/duplications in parkin gene
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2016.1255612
Abstract: ABSTRACT Aim of the study: Mutations in PARK2 are one of the causes of Parkinson's disease (PD). Deletions and duplications/triplications of one exon or exon groups account for a large proportion of mutations in the… read more here.
Keywords: patients sporadic; deletions duplications; parkinson disease; park2 ... See more keywords
Definition of a putative pathological region in PARK2 associated with autism spectrum disorder through in silico analysis of its functional structure
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000159
Abstract: Objective The PARK2 gene encodes Parkin, a component of a multiprotein E3 ubiquitin ligase complex that targets substrate proteins for proteasomal degradation. PARK2 mutations are frequently associated with Parkinson’s disease, but structural alterations have also… read more here.
Keywords: definition putative; analysis; putative pathological; pathological region ... See more keywords
PARK2 Regulates eIF4B-Driven Lymphomagenesis
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DOI: 10.1158/1541-7786.mcr-21-0729
Abstract: Abstract Patients with high-risk diffuse large B-cell lymphoma have poor outcomes following first-line cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP); thus, treatment of this fatal disease remains an area of unmet medical need and requires… read more here.
Keywords: park2 regulates; lymphomagenesis; protein translation; park2 ... See more keywords
PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0058
Abstract: Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson’s disease, plays an important role in… read more here.
Keywords: osteoclastogenesis activation; osteoclastogenesis; bone; park2 induces ... See more keywords
PARK2 Suppresses Proliferation and Tumorigenicity in Non-small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00790
Abstract: Aims: PARK2 mutation is originally associated with the progression of Parkinson's disease. In recent years, PARK2 has been reported as a tumor suppressor gene in various cancers, including lung cancer. However, the biological functions and… read more here.
Keywords: park2; non small; cell; lung cancer ... See more keywords
PARK2 negatively regulates the metastasis and epithelial-mesenchymal transition of glioblastoma cells via ZEB1
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.6488
Abstract: Glioblastoma multiforme (GBM), one of the most aggressive human malignant brain tumors, is induced by multiple complex pathological mechanisms. The main cause of mortality in patients with GBM is the invasion-metastasis cascade of tumor cells.… read more here.
Keywords: mesenchymal transition; glioblastoma; metastasis; zeb1 ... See more keywords