Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01113
Abstract: The multifunctional human Parkinson’s disease protein 7 (PARK7/DJ1) is an attractive therapeutic target due to its link with early-onset Parkinson’s disease, upregulation in various cancers, and contribution to chemoresistance. However, only a few compounds have… read more here.
Keywords: toolkit park7; high throughput; chemical toolkit; park7 ... See more keywords
Immunomodulatory role of Parkinson’s disease 7 in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93671-1
Abstract: Recently the role of Parkinson’s disease 7 (PARK7) was studied in gastrointestinal diseases, however, the complex role of PARK7 in the intestinal inflammation is still not completely clear. Expression and localization of PARK7 were determined… read more here.
Keywords: inflammatory bowel; disease; role parkinson; park7 ... See more keywords
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111338119
Abstract: Significance Reactive compounds cause cellular damage that is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely contribute to this. Here we report that an enzyme mutated in Parkinson’s disease… read more here.
Keywords: glycolytic metabolite; parkinson disease; park7; damage ... See more keywords
PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/4787202
Abstract: Coeliac disease (CD) is a chronic, immune-mediated small intestinal enteropathy, accompanied with gluten-triggered oxidative damage of duodenal mucosa. Previously, our research group reported an increased mucosal level of the antioxidant protein Parkinson's disease 7 (PARK7)… read more here.
Keywords: disease; mucosal; park7; damage ... See more keywords
PARK7 regulates inflammation-induced pro-labour mediators in myometrial and amnion cells.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-17-0604
Abstract: Preterm birth is a prevalent cause of neonatal deaths worldwide. Inflammation has been implicated in spontaneous preterm birth involved in the processes of uterine contractility and membrane rupture. Parkinson protein 7 (PARK7) has been found… read more here.
Keywords: amnion cells; labour mediators; inflammation; park7 ... See more keywords
Plasma PARK7 and NDKA in acute stroke: methodological issues regarding diagnostic value
Sign Up to like & getrecommendations! Published in 2019 at "Future Science OA"
DOI: 10.2144/fsoa-2019-0078
Abstract: I read a recently published article by Tulantched et al. in Future Science OA. The purpose of this study was to compare the diagnostic value of plasma PARK7 and NDKA in early diagnosis of acute… read more here.
Keywords: park7 ndka; park7; acute stroke; diagnostic value ... See more keywords