Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22495
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene,… read more here.
Keywords: polyubiquitination; ape1; apurinic apyrimidinic; parkin ... See more keywords
Synaptotagmin‐11 Is a novel hotspot in the pathogenesis of parkin‐linked Parkinson's disease: New implications for clinical targeting
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27369
Abstract: Of several identified loci, Syt-11, the encoding gene for synaptotagmin-11, is of the hottest PD risk genes. Syt-11 is a non-Ca-binding Syt and cause the inhibition of neural endocytosis and therefor vesicle recycling. Of note,… read more here.
Keywords: accumulation; wang colleagues; syt; endocytosis ... See more keywords
Activation of PINK1/Parkin-mediated mitophagy protects against apoptosis in kidney damage caused by aluminum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2022.111765
Abstract: Aluminum (Al) induces apoptosis via oxidative stress and/or mitochondrial damage. Kidney is the main organ of Al excretion, but whether Al causes apoptosis in kidney of mice remains unclear. Mitophagy maintains cell homeostasis via clearing… read more here.
Keywords: damage; kidney damage; parkin; mediated mitophagy ... See more keywords
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00474-x
Abstract: Dear Editor, The loss of PINK1/Parkin-dependent mitochondrial clearance causes loss of dopaminergic neurons in the substantia nigra and contributes to the pathogenesis of Parkinson’s disease (PD). Several kinases were reported to regulate the ubiquitin E3… read more here.
Keywords: shp2; supplementary fig; fig supplementary; fig ... See more keywords
Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210741
Abstract: The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed by… read more here.
Keywords: acceptor; omm; parkin; phosphorylation ... See more keywords
PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1716506115
Abstract: Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by progressive deterioration of motor function caused by loss of dopamine-producing neurons. Currently, there is no treatment that could stop the… read more here.
Keywords: ligase activity; parkin; ubiquitin ligase; pick1 ... See more keywords
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac297
Abstract: Abstract Abnormal lipid homeostasis has been observed in the brain of Parkinson’s disease (PD) patients and experimental models, although the mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that the PD-linked protein… read more here.
Keywords: lipid homeostasis; parkinson disease; srebp2; homeostasis ... See more keywords
Structure-based design and characterization of Parkin-activating mutations
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2022.02.22.481412
Abstract: Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and… read more here.
Keywords: activating mutations; parkinson disease; design; structure based ... See more keywords
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13834
Abstract: Microglial hyperactivation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver… read more here.
Keywords: parkin regulates; parkinson disease; regulates microglial; microglial nlrp3 ... See more keywords
Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15917
Abstract: Increasing evidence suggests that astrocytes play an important role in the progression of Parkinson's disease (PD). Previous studies on our parkin knockout mouse demonstrated a higher accumulation of damaged mitochondria in astrocytes than in surrounding… read more here.
Keywords: loss parkin; endoplasmic reticulum; calcium dyshomeostasis; parkin ... See more keywords
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.127713
Abstract: The E3 ubiquitin ligase Parkin plays an important role in regulating clearance of dysfunctional or unwanted mitochondria in tissues, including the heart. However, whether Parkin also functions to prevent cardiac aging by maintaining a healthy… read more here.
Keywords: polg; cardiac aging; mice; mitochondrial dna ... See more keywords