Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12988
Abstract: Sarcopenia is characterized by the loss of skeletal muscle mass and strength and is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) exposure, a major cause for COPD,… read more here.
Keywords: obstructive pulmonary; chronic obstructive; related sarcopenia; pulmonary disease ... See more keywords
Induction of PINK1/Parkin-Mediated Mitophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_7
Abstract: PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are… read more here.
Keywords: mediated mitophagy; pink1; pink1 parkin; parkin mediated ... See more keywords
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109884
Abstract: Aflatoxin B1 (AFB1) is a toxic food pollutant that has extensive deleterious impacts on the kidney. Oxidative stress represents the primary mechanism of AFB1 nephrotoxicity and can also cause mitochondrial damage. Damaged mitochondria can trigger… read more here.
Keywords: damage; kidney damage; mediated mitophagy; parkin mediated ... See more keywords
Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz002
Abstract: Abstract The development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. The mechanisms of morphine tolerance are poorly understood. Mitochondria-derived reactive oxygen species (ROS) is a crucial signal… read more here.
Keywords: tolerance; pink1 parkin; morphine; parkin mediated ... See more keywords
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/2640209
Abstract: San-Huang-Yi-Shen capsule (SHYS) has been used in the treatment of diabetic kidney disease (DKD) in clinics. However, the mechanism of SHYS on DKD remains unclear. In this study, we used a high-fat diet combined with… read more here.
Keywords: pink1 parkin; mediated mitophagy; activation nlrp3; parkin mediated ... See more keywords
Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-021-00243-4
Abstract: Background Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin… read more here.
Keywords: mediated mitophagy; pink1; vps35; parkinson disease ... See more keywords
The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.260395
Abstract: ABSTRACT Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex initiates mitophagosome formation remains unknown. The Rab7 GTPase (herein referring… read more here.
Keywords: ser phosphorylation; rab7; ulk complex; mitophagy ... See more keywords
PINK1/parkin-mediated mitophagy alleviates Staphylococcus aureus-induced NLRP3 inflammasome and NF-κB pathway activation in bovine mammary epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4161486
Abstract: Staphylococcus aureus (S. aureus) is known to induce chronic and persistent bovine mammary infection, which affects milk quality and leads to premature culling. The ability of S. aureus to invade mammalian cells protects it from… read more here.
Keywords: staphylococcus aureus; bovine; parkin mediated; pink1 parkin ... See more keywords
PINK1/Parkin-Mediated Mitochondrial Autophagy Participates in H2O2-Induced Abnormal Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s398690
Abstract: Introduction To explore the role of PINK1/Parkin-mediated mitochondrial autophagy in H2O2-induced abnormal proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Methods Firstly, we isolated fibroblast like synoviocytes (RA-FLS) from RA patients. H2O2-induced oxidative stress, and NAC… read more here.
Keywords: proliferation; parkin mediated; pink1 parkin; mitochondrial autophagy ... See more keywords
Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.813370
Abstract: Doxorubicin (DOX) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe risk of cardiotoxicity. One of the hallmarks of doxorubicin-induced cardiotoxicity (DICT) is the cascade of… read more here.
Keywords: har; dict; p53 parkin; cardiotoxicity ... See more keywords
Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1031153
Abstract: The selective degradation of mitochondria through mitophagy is a crucial process for maintaining mitochondrial function and cellular health. Mitophagy is a specialized form of selective autophagy that uses unique machinery to recognize and target damaged… read more here.
Keywords: defective pten; kinase parkin; pten induced; induced kinase ... See more keywords