Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2692-9
Abstract: Neurons are highly specialised cells with a large bioenergetic demand, and so require a healthy mitochondrial network to function effectively. This network is compromised in many neurological disorders, in which damaged mitochondria accumulate. Dysfunctional mitochondria… read more here.
Keywords: evidence; parkin mitophagy; mitophagy vivo; pink1 parkin ... See more keywords
Parkin and mitophagy in cancer
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DOI: 10.1038/onc.2016.302
Abstract: Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted… read more here.
Keywords: mitophagy cancer; parkin mitophagy; number; cancer ... See more keywords
The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells
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DOI: 10.1371/journal.pone.0259903
Abstract: Mutations in the PINK1 and PRKN genes are the most common cause of early-onset familial Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively, which are involved in the degradation of dysfunctional… read more here.
Keywords: blood mononuclear; parkin mitophagy; peripheral blood; pink1 parkin ... See more keywords