PINK1/Parkin Pathway Activation for Mitochondrial Quality Control – Which Is the Best Molecular Target for Therapy?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.890823
Abstract: There has been long-term interest in drugging the PINK1-Parkin pathway with therapeutics as a treatment for Parkinson’s disease (PD). Despite significant structural data on Parkin as well as the PINK1 kinase and the multiple conformational… read more here.
Keywords: parkin pathway; pink1 parkin; pathway activation; pathway ... See more keywords
Dictyophora Polysaccharide Attenuates As-Mediated PINK1/Parkin Pathway-Induced Mitophagy in L-02 Cell through Scavenging ROS
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092806
Abstract: Arsenic (As) is common in the human living environment and a certain amount of exposure to As can lead to liver damage; this toxic effect has been proved to be closely related to intracellular PINK1/Parkin… read more here.
Keywords: dictyophora polysaccharide; parkin pathway; scavenging ros; mitophagy ... See more keywords
Effect on hypoxia/reoxygenation-induced cardiomyocyte injury and Pink1/Parkin pathway.
Sign Up to like & getrecommendations! Published in 2023 at "General physiology and biophysics"
DOI: 10.4149/gpb_2022045
Abstract: Our study aimed to detect the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) on exacerbating cardiomyocyte hypoxia/reoxygenation (H/R) injury and the possible mechanism. A cell model of H/R was constructed. PCSK9 mRNA and protein… read more here.
Keywords: pink1 parkin; parkin pathway; pink1; hypoxia reoxygenation ... See more keywords