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Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.

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2 Published in 2023 at "Aging cell"

DOI: 10.1111/acel.13834

Abstract: Microglial hyperactivation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver… read more here.

Keywords: parkin regulates; parkinson disease; regulates microglial; microglial nlrp3 ... See more keywords