A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling
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DOI: 10.1016/j.isci.2020.101048
Abstract: Summary Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial dysfunction. We report two chemical enhancers of PINK1-Parkin signaling,… read more here.
Keywords: based high; cell based; parkin signaling; pink1 parkin ... See more keywords
Paraquat Exposure Induces Pulmonary Cell Mitophagy by Enhancing the PINK1/Parkin Signaling
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DOI: 10.1155/2020/7103105
Abstract: Paraquat (PQ) poisoning can cause oxidative stress, acute lung injury (ALI), and fibrosis. Excess oxidative stress can induce mitophagy. However, whether PQ exposure can induce mitophagy, contributing to the development of ALI and pulmonary fibrosis… read more here.
Keywords: exposure; exposure induces; expression; parkin signaling ... See more keywords
FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway
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DOI: 10.7150/jca.82949
Abstract: Background: There is growing evidence that aberrant expression of FAM72A contributes to biological dysfunction, especially mitochondrial dysfunction. However, its role in most tumors remains unclear, especially in glioma. Methods: Herein, a high-throughput sequencing approach was… read more here.
Keywords: pink1 parkin; signaling pathway; parkin signaling; glioma progression ... See more keywords
Cinnamaldehyde regulates mitochondrial quality against hydrogen peroxide induced apoptosis in mouse lung mesenchymal stem cells via the PINK1/Parkin signaling pathway
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DOI: 10.7717/peerj.14045
Abstract: Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease without effective treatments. Mitochondrial dysfunction weakens the ability of mesenchymal stem cells (MSCs) to repair the distal lung epithelium, which is a probable pathogenesis of… read more here.
Keywords: signaling pathway; parkin signaling; lung; mesenchymal stem ... See more keywords