Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.007
Abstract: Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been proposed for explanation of the molecular mechanisms of… read more here.
Keywords: intrinsically disordered; biology; parkinson diseases; disordered proteins ... See more keywords
Combustion and friction-derived nanoparticles and industrial-sourced nanoparticles: The culprit of Alzheimer and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.108574
Abstract: Redox-active, strongly magnetic, combustion and friction-derived nanoparticles (CFDNPs) are abundant in particulate matter air pollution. Urban children and young adults with Alzheimer disease Continuum have higher numbers of brain CFDNPs versus clean air controls. CFDNPs… read more here.
Keywords: combustion friction; parkinson diseases; derived nanoparticles; alzheimer parkinson ... See more keywords
Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00679
Abstract: Recent advancements in lactoferrin research have uncovered that lactoferrin does function not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and neuroprotective agent. Focusing on neuroprotection, this literature review delineates how lactoferrin… read more here.
Keywords: alzheimer parkinson; review; neuroprotective effects; parkinson diseases ... See more keywords
Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15697
Abstract: Extracellular vesicles (EVs) are gaining increased importance in fundamental research as key players in disease pathogenic mechanisms, but also in translational and clinical research due to their value in biomarker discovery, either for diagnostics and/or… read more here.
Keywords: evs isolation; extracellular vesicles; alzheimer parkinson; parkinson diseases ... See more keywords
Gene Therapy for Alzheimer and Parkinson Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Current gene therapy"
DOI: 10.2174/1566523223666230419101023
Abstract: Alzheimer and Parkinson diseases are associated with cholinergic neuron loss and deterioration of bone mineral density. Gene therapy through either gene transfer, CRISPR gene editing, or CRISPR gene modulation holds the potential to cure Alzheimer… read more here.
Keywords: parkinson diseases; gene; gene therapy; alzheimer parkinson ... See more keywords
Ultrasensitive detection of blood biomarkers of Alzheimer's and Parkinson's diseases: a systematic review.
Sign Up to like & getrecommendations! Published in 2021 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0219
Abstract: Purpose: Neurodegenerative disorders are a global health burden with costly and invasive diagnoses relying on brain imaging technology or CSF-based biomarkers. Therefore, considerable efforts to identify blood-biomarkers for Alzheimer's (AD) and Parkinson's diseases (PD) are… read more here.
Keywords: parkinson diseases; systematic review; blood; biomarkers alzheimer ... See more keywords
Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Acta Naturae"
DOI: 10.32607/20758251-2017-9-1-26-37
Abstract: In our previous review, we described brain cholesterol metabolism in control conditions and in the case of some rare neurological pathologies linked to defects in the genes which are directly involved in the synthesis and/or… read more here.
Keywords: parkinson diseases; diseases autism; cholesterol homeostasis; cholesterol ... See more keywords
Parkin as a Molecular Bridge Linking Alzheimer’s and Parkinson’s Diseases?
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040559
Abstract: Alzheimer’s (AD) and Parkinson’s (PD) diseases are two distinct age-related pathologies that are characterized by various common dysfunctions. They are referred to as proteinopathies characterized by ubiquitinated protein accumulation and aggregation. This accumulation is mainly… read more here.
Keywords: molecular bridge; parkin molecular; parkinson diseases; alzheimer parkinson ... See more keywords
Alternative Splicing and Hypoxia Puzzle in Alzheimer’s and Parkinson’s Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12081272
Abstract: Alternative pre-mRNA splicing plays a very important role in expanding protein diversity as it generates numerous transcripts from a single protein-coding gene. Therefore, alterations lead this process to neurological human disorders, including Alzheimer’s and Parkinson’s… read more here.
Keywords: alzheimer parkinson; splicing hypoxia; alternative splicing; parkinson diseases ... See more keywords