A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-223452
Abstract: Injections of pre-formed α-synuclein fibrils (PFFs) or overexpression of α-synuclein using AAV vectors are commonly used as models of Parkinson-like synucleinopathy in rats and mice. In the modified method reviewed here, the “SynFib” model, the… read more here.
Keywords: synfib model; parkinson like; dopamine; pathology ... See more keywords
New models of Parkinson’s like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1038721
Abstract: Microglia activation and neuroinflammation have been extensively studied in murine models of neurodegenerative diseases; however, to overcome the genetic differences between species, a human cell model of microglia able to recapitulate the activation profiles described… read more here.
Keywords: models parkinson; parkinson like; like neuroinflammation; human microglia ... See more keywords
Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports
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DOI: 10.3389/fphar.2020.00315
Abstract: Introduction Since vascular endothelial growth factor (VEGF) regulates several aspects of the central nervous system, particularly in dopaminergic neurons, VEGF inhibitors may be linked to Parkinson-like events and dementia, or variants of these diseases. Two… read more here.
Keywords: anti vegf; like events; intravitreal anti; parkinson ... See more keywords