Individual parkinsonian motor signs and striatal dopamine transporter deficiency: a study with [I-123]FP-CIT SPECT
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09202-6
Abstract: IntroductionTotal parkinsonian motor symptom severity correlates with presynaptic striatal dopamine function in patients with Parkinson’s disease. There is a lack of studies that have investigated the associations between parkinsonian motor signs and striatal dopaminergic deficiency… read more here.
Keywords: parkinsonian motor; motor signs; motor; striatal dopamine ... See more keywords
Parkinsonian motor impairment predicts personality domains related to genetic risk and treatment outcomes in schizophrenia
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DOI: 10.1038/npjschz.2016.36
Abstract: Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for… read more here.
Keywords: parkinsonian motor; treatment outcomes; motor impairment; treatment ... See more keywords
Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213093120
Abstract: Significance Dopamine (DA) is critical for movements, and its loss causes debilitating motor deficits in Parkinson’s disease (PD). However, dopamine is also strongly implicated in reward learning. Here, we used two distinct motor tasks to… read more here.
Keywords: parkinsonian motor; motor deficits; critically drives; motor ... See more keywords
The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB
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DOI: 10.5607/en21007
Abstract: The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the proposal that reactive astrocytes… read more here.
Keywords: parkinsonian motor; genetic ablation; astrocytic maob; motor symptoms ... See more keywords