Atypical Parkinsonian Syndromes and Subtypes of Parkinson's Disease. Will a Single Neuroimaging Modality Ever Be Enough?
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13137
Abstract: Despite the continuous refining of clinical criteria and consensus statements, the differential diagnosis between idiopathic Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS), particularly at the early stages of these conditions, remains challenging even in… read more here.
Keywords: parkinsonian syndromes; atypical parkinsonian; diagnosis; cmri ... See more keywords
"De-novo" consultation: Evaluation of an outpatient's clinic dedicated to early diagnosis of parkinsonian syndromes.
Sign Up to like & getrecommendations! Published in 2017 at "Revue neurologique"
DOI: 10.1016/j.neurol.2016.12.031
Abstract: INTRODUCTION In the absence of specific clinical signs, imaging or biomarkers, the differential diagnosis of degenerative parkinsonian syndromes may be difficult at early stages of the disease. To reduce the risk of misdiagnosis or delayed… read more here.
Keywords: parkinsonian syndromes; diagnosis; diagnosis parkinsonian; early diagnosis ... See more keywords
Atypical parkinsonian syndromes: a general neurologist's perspective
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neurology"
DOI: 10.1111/ene.13412
Abstract: The differential diagnosis of atypical parkinsonian syndromes is challenging. These severe and often rapidly progressive neurodegenerative disorders are clinically heterogeneous and show significant phenotypic overlap. Here, clinical, imaging, neuropathological and genetic features of multiple system… read more here.
Keywords: parkinsonian syndromes; general neurologist; atypical parkinsonian; degeneration ... See more keywords
Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes.
Sign Up to like & getrecommendations! Published in 2021 at "Radiology"
DOI: 10.1148/radiol.2021203341
Abstract: Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. There are various imaging markers for Parkinson disease. Recent advances in MRI have enabled elucidation of the underlying pathophysiologic changes… read more here.
Keywords: parkinsonian syndromes; disease; substantia nigra; parkinson disease ... See more keywords
Transcranial brain sonography for Parkinsonian syndromes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurosurgical sciences"
DOI: 10.23736/s0390-5616.19.04696-4
Abstract: Substantia nigra (SN) hyperechogenicity has been proved to be a characteristic finding for idiopathic Parkinson's disease (PD), occurring in more than 90% of the patients. This echofeature is owed to increased amounts of iron in… read more here.
Keywords: brain sonography; diagnosis; parkinsonian syndromes; predictive value ... See more keywords
Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.917706
Abstract: Background Parkinsonian syndromes may rarely occur in motor neuron disease (MND). However, previous studies are heterogeneous and mostly case reports or small case series. Therefore, we aimed to identify and characterize patients with concurrent parkinsonian… read more here.
Keywords: disease; neuron disease; parkinsonian syndromes; parkinsonism ... See more keywords
Magnetic resonance imaging modalities aid in the differential diagnosis of atypical parkinsonian syndromes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1082060
Abstract: Accurate and timely diagnosis of atypical parkinsonian syndromes (APS) remains a challenge. Especially early in the disease course, the clinical manifestations of the APS overlap with each other and with those of idiopathic Parkinson's disease… read more here.
Keywords: magnetic resonance; resonance imaging; diagnosis; atypical parkinsonian ... See more keywords
Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.720220
Abstract: Background: Atypical parkinsonian syndromes are rare, fatal neurodegenerative diseases associated with abnormal protein accumulation in the brain. Examples of these syndromes include progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. A common clinical feature… read more here.
Keywords: parkinsonian syndromes; therapy treatment; atypical parkinsonian; disease modifying ... See more keywords
Coenzyme Q10 and Parkinsonian Syndromes: A Systematic Review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12060975
Abstract: Coenzyme Q10 (CoQ10) has an important role as an antioxidant. Being that oxidative stress is one of the mechanisms involved in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative diseases, several studies addressed the… read more here.
Keywords: coq10; parkinsonian syndromes; systematic review; coenzyme q10 ... See more keywords
MicroRNA as Candidate Biomarkers in Atypical Parkinsonian Syndromes: Systematic Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58040483
Abstract: Background and Objectives: Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are rare atypical parkinsonian syndromes, characterized by motor and cognitive symptoms. Their clinical diagnosis is challenging because there are no established biomarkers. Dysregulation… read more here.
Keywords: microrna candidate; systematic literature; atypical parkinsonian; parkinsonian syndromes ... See more keywords
LC-MS/MS Determination of Modified Nucleosides in The Urine of Parkinson’s Disease and Parkinsonian Syndromes Patients
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25214959
Abstract: Epigenetic modifications play a key role in gene regulation and expression and are involved in numerous cellular processes. Due to the limited research on nucleosides in Parkinson’s disease (PD), it is very important to consider… read more here.
Keywords: parkinsonian syndromes; determination modified; modified nucleosides; parkinson disease ... See more keywords