Phenotypic evaluation of a childhood-onset parkinsonism-dystonia mouse model with inherent postural abnormalities
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.10.018
Abstract: Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We… read more here.
Keywords: onset parkinsonism; parkinsonism dystonia; model; postural abnormalities ... See more keywords
Parkinsonism and dystonia are differentially induced by modulation of different territories in the basal ganglia
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DOI: 10.1016/j.neuroscience.2017.03.063
Abstract: Numerous clinical and experimental observations suggest that deficient neuronal signaling in the globus pallidus externa (GPe) is integral to both Parkinson's disease (PD) and dystonia. In our previous studies in jaundiced dystonic rats, widespread silencing… read more here.
Keywords: dystonia differentially; parkinsonism dystonia; dystonia; motor ... See more keywords
Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.68039
Abstract: Parkinson disease (PD) is a progressive, neurodegenerative disorder affecting over 6.1 million people worldwide. Although the cause of PD remains unclear, studies of highly penetrant mutations identified in early-onset familial parkinsonism have contributed to our… read more here.
Keywords: infantile parkinsonism; hdat r445c; parkinsonism; parkinsonism dystonia ... See more keywords