The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0605-6
Abstract: Ischemic stroke is a debilitating multi-factorial cerebrovascular disorder, representing an area of tremendous unmet medical need. Combination treatment has been proposed as a promising therapeutic approach towards combating ischemic stroke. The present study employs in… read more here.
Keywords: combination; post ischemic; treatment; paroxetine ... See more keywords
Beneficial effects of irisin in experimental paroxetine-induced hyperprolactinemia
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine"
DOI: 10.1007/s12020-022-03010-1
Abstract: It is known that selective serotonin reuptake inhibitors (SSRIs), represent an important and effective treatment of depression and other psychological disorders, these medications can increase prolactin levels mainly through activation of the serotonergic pathway. In… read more here.
Keywords: induced hyperprolactinemia; paroxetine; paroxetine induced; beneficial effects ... See more keywords
Joint replenishment of zinc and folic acid enhances the anti-depressive effect of paroxetine via increasing serum calcium and copper and decreasing serum arsenic
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135270
Abstract: Insufficient zinc and folic acid levels are associated with depression and poor response to antidepressants. This study aimed to investigate the influences of combined zinc and folic acid replenishment on the anti-depressive effect of paroxetine.… read more here.
Keywords: folic acid; paroxetine; zinc folic; anti depressive ... See more keywords
Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00112
Abstract: In heart failure, the β-adrenergic receptors (βARs) become desensitized and uncoupled from heterotrimeric G proteins. This process is initiated by G protein-coupled receptor kinases (GRKs), some of which are upregulated in the failing heart, making… read more here.
Keywords: protein coupled; structure based; coupled receptor; paroxetine ... See more keywords
Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001096
Abstract: BACKGROUND Paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome P450 (CYP)2D6. Only small-scale studies have reported the impact of CYP2D6 genotype on paroxetine exposure, and international guidelines differ in their recommendations on whether… read more here.
Keywords: paroxetine; cyp2d6; impact cyp2d6; cyp2d6 genotype ... See more keywords
Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine‐treated rats
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13371
Abstract: In comparison to other antidepressant drugs, erectile dysfunction (ED) is more pronounced in paroxetine use. On the other hand, orange (Citrus sinensis) peels commonly consumed in various forms are used in folkloric medicine for ED… read more here.
Keywords: paroxetine; paroxetine induced; treated rats; paroxetine treated ... See more keywords
Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14261
Abstract: This study focused on the effect of unripe (UPP) and ripe (RPP) plantain peels' extracts (200 and 400 mg/kg) on sexual behavior, hormonal profiles [testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH)], and enzymes [acetylcholinesterase (AChE),… read more here.
Keywords: sexual performance; male; paroxetine; peels restore ... See more keywords
Precision dosing‐based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13281
Abstract: Paroxetine has been demonstrated to undergo gestation‐related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking. read more here.
Keywords: paroxetine pregnancy; dosing based; optimisation paroxetine; precision dosing ... See more keywords
Therapeutic Response to Paroxetine in Major Depressive Disorder Predicted by DNA Methylation
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychobiology"
DOI: 10.1159/000480512
Abstract: Background: Antidepressants have variable therapeutic effects, depending on genetic and environmental factors. Approximately 30% of major depressive disorder (MDD) patients do not respond significantly to antidepressants such as paroxetine, a selective serotonin reuptake inhibitor (SSRI).… read more here.
Keywords: methylation; depressive disorder; paroxetine; major depressive ... See more keywords
Effects of CYP2D6*4 polymorphism on the steady-state concentration of paroxetine in patients diagnosed with depressive episode and comorbid alcohol use disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221112939
Abstract: Introduction: Selective serotonin reuptake inhibitors have a common and increasing use for the treatment of patients diagnosed with depressive disorders. Some of them do not respond adequately to therapy, and numerous previous studies have indicated… read more here.
Keywords: polymorphism; paroxetine; diagnosed depressive; concentration ... See more keywords
Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-1712-0
Abstract: Background Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced… read more here.
Keywords: inflammatory responses; lps induced; primary astrocytes; microglia mediated ... See more keywords