Novel splice‐switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action
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DOI: 10.1002/ijc.30574
Abstract: Tumors carrying hereditary mutations in BRCA1, which attenuate the BRCA1 DNA damage repair pathway, are more susceptible to dual treatment with PARP inhibitors and DNA damaging therapeutics. Conversely, breast cancer tumors with nonmutated functional BRCA1… read more here.
Keywords: susceptibility parp; brca1; parp inhibitor; splice switching ... See more keywords
PARP inhibition by olaparib alleviates chronic asthma‐associated remodeling features via modulating inflammasome signaling in mice
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DOI: 10.1002/iub.2048
Abstract: Despite the reported role of poly(ADP‐ribose) polymerase (PARP) in asthma inflammation, its contribution during remodeling is not clearly known. The main aim of the current investigation was to examine the potential of olaparib, a pharmacological… read more here.
Keywords: olaparib; via modulating; inflammasome signaling; chronic asthma ... See more keywords
Flavonoids of Rosa roxburghii Tratt Exhibit Anti‐Apoptosis Properties by Regulating PARP‐1/AIF
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26049
Abstract: Radioprotection is an important approach to reduce the side‐effects of radiotherapy. The radioprotective effect of the flavonoids of Rosa roxburghii Tratt (FRT) has been confirmed, and the mechanism has been identified as theBcl‐2/caspase‐3/PARP‐1 signaling pathway.… read more here.
Keywords: apoptosis; frt; flavonoids rosa; rosa roxburghii ... See more keywords
Strategies Employed for the Development of PARP Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6993-7_18
Abstract: This chapter describes the approaches taken in the development of the first PARP inhibitor to enter clinical trial, rucaparib (now called Rubraca), in 2003. We describe the general principles of crystal-based drug design, the purification… read more here.
Keywords: parp inhibitors; employed development; parp; development parp ... See more keywords
Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05189-w
Abstract: PurposeTargeting DNA repair mechanisms to induce apoptosis may be a promising strategy for breast cancer treatment. Olaparib is proved to have anticancer effect by inhibiting DNA repairing protein poly (ADP-ribose) polymerase (PARP). However, the cytotoxicity… read more here.
Keywords: olaparib treatment; breast cancer; ape1; parp ... See more keywords
Design of potential anti-tumor PARP-1 inhibitors by QSAR and molecular modeling studies
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DOI: 10.1007/s11030-020-10063-9
Abstract: Abstract Poly ADP-ribose polymerase-1 (PARP-1) inhibitors have been recognized as new agents for the treatment of patients with breast cancer type 1 (BRCA1) disorders. The quantitative structure–activity relationships (QSAR) technique was used in order to… read more here.
Keywords: parp inhibitors; design potential; potential anti; anti tumor ... See more keywords
Identification of PARP-1 in cancer stem cells of gastrointestinal cancers: A preliminary study
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DOI: 10.1007/s12038-020-00135-1
Abstract: Advanced-stage gastrointestinal tumors have high mortality due to chemotherapy limitations. One of the causes of treatment failure is the presence of cancer stem cells (CSCs), which show resistance mechanisms against DNA damage, such as poly… read more here.
Keywords: cancer stem; parp; cancer; parp cancer ... See more keywords
Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103181
Abstract: Two new series of compounds were designed and synthesized as potent PARP-1 inhibitors. These compounds were evaluated for PARP-1 enzyme and cellular inhibitory activities. All efforts lead to the identification of 9k (named as LG-12)… read more here.
Keywords: parp inhibitors; design synthesis; potent parp; evaluation ... See more keywords
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.06.023
Abstract: Glioblastoma (GBM) is the most common primary brain tumor and is highly aggressive with a median survival of 15 months. We have previously shown that residual cells of GBM form multinucleated giant cells (MNGCs) showing… read more here.
Keywords: parp activity; recurrence; parp; inhibition parp ... See more keywords
PARP Inhibitors for Cancer Therapy
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DOI: 10.1016/j.cell.2017.03.034
Abstract: Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to selective killing… read more here.
Keywords: parp inhibitors; parp; cancer; inhibitors cancer ... See more keywords
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2020.102973
Abstract: The prognosis of recurrent or metastatic endometrial cancer is poor, with five-year survival of only 10-20 %. First-line therapy consists of either platinum-based chemotherapy or hormonal therapy. No standard subsequent-line therapy has been identified. In… read more here.
Keywords: recurrent metastatic; parp; inhibition; endometrial cancer ... See more keywords