Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.06.023
Abstract: Glioblastoma (GBM) is the most common primary brain tumor and is highly aggressive with a median survival of 15 months. We have previously shown that residual cells of GBM form multinucleated giant cells (MNGCs) showing… read more here.
Keywords: parp activity; recurrence; parp; inhibition parp ... See more keywords
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1317413
Abstract: ABSTRACT Bloom Syndrome (BS) is a rare genetic disease characterized by high levels of chromosomal instability and an increase in cancer risk. Cytidine deaminase (CDA) expression is downregulated in BS cells, leading to an excess… read more here.
Keywords: chromatid disjunction; sister chromatid; parp activity; cytidine deaminase ... See more keywords
Epigenetic Insights on PARP-1 Activity in Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010006
Abstract: Simple Summary PARP-1 and poly(ADP-ribosyl)ation control gene expression, DNA repair pathways, and genomic stability in multiple ways, such as affecting chromatin remodelling. This review article summarises how PARP-1 activity directly modifies histone proteins and the… read more here.
Keywords: dna; histone; therapy; activity ... See more keywords
Modulation of PARP-1 Activity in a Broad Time Window Attenuates Memorizing Fear
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126170
Abstract: The amygdala plays a critical role in the acquisition and consolidation of fear-related memories. Recent studies have demonstrated that ADP-ribosylation of histones, accelerated by PARPs, affects the chromatin structure and the binding of chromatin remodeling… read more here.
Keywords: time window; parp activity; time; broad time ... See more keywords