PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
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DOI: 10.1158/0008-5472.can-21-0628
Abstract: This study demonstrates that PARP and ATR inhibitors are synthetic lethal with the loss of PBRM1, a PBAF-specific subunit, thus providing the rationale for assessing these inhibitors in patients with PBRM1-defective cancer. Inactivation of Polybromo… read more here.
Keywords: pbrm1; parp atr; pbrm1 defective; cancer ... See more keywords