PARP inhibition in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1002/gcc.22903
Abstract: Defects in DNA damage repair genes are more common in prostate cancer than previously thought. These alterations provide an opportunity for precision oncology approaches and a number of studies have now shown that PARP inhibitors… read more here.
Keywords: cancer; parp inhibition; prostate cancer;
PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.054
Abstract: SUMMARY PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However, the therapeutic mechanisms of action for PARP inhibition in the interaction of… read more here.
Keywords: antitumor immunity; parp inhibition; inhibition; ovarian cancer ... See more keywords
Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01352
Abstract: The nuclear enzymes called poly(ADP-ribose)polymerases (PARPs) are known to catalyze the process of PARylation, which plays a vital role in various cellular functions. They have become important targets for the discovery of novel antitumor drugs… read more here.
Keywords: based parp; therapies based; inhibition; parp inhibition ... See more keywords
PARP inhibition in breast cancer: progress made and future hopes
Sign Up to like & getrecommendations! Published in 2022 at "npj Breast Cancer"
DOI: 10.1038/s41523-022-00411-3
Abstract: PARP inhibitors have been approved for the treatment of metastatic breast cancer in germline BRCA mutation (g BRCA m) carriers. The recent OlympiA trial demonstrated improved progression-free and distant disease-free survival with adjuvant olaparib for… read more here.
Keywords: cancer; breast cancer; parp inhibitors; inhibition breast ... See more keywords
First-line PARP inhibition in ovarian cancer — standard of care for all?
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0335-9
Abstract: In 2018, the SOLO1 trial set a new standard of care with maintenance olaparib substantially extending progression-free survival (PFS) in women with newly-diagnosed BRCA1/2 -mutated advanced-stage ovarian cancer. Herein, we summarize trials of first-line poly(ADP-ribose)… read more here.
Keywords: first line; parp inhibition; ovarian cancer; standard care ... See more keywords
STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005627
Abstract: Background Poly (ADP-ribose) polymerase (PARP) inhibition (PARPi) has demonstrated potent therapeutic efficacy in patients with BRCA-mutant ovarian cancer. However, acquired resistance to PARPi remains a major challenge in the clinic. Methods PARPi-resistant ovarian cancer mouse… read more here.
Keywords: parpi; ovarian cancer; resistance; parp inhibition ... See more keywords
PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-0317
Abstract: Purpose: In this study, we addressed the underlying mechanisms for the association between enzalutamide (ENZ) treatment and neuroendocrine prostate cancer (NEPC), and the critical involvement of MYCN, and loss of RB1 function in neuroendocrine differentiation… read more here.
Keywords: parp inhibition; prostate cancer; rb1; cancer ... See more keywords
Abstract 958: PARP-inhibition induces cancer immunogenic cell death in response to high levels of interferon-gamma in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-958
Abstract: Background: We recently demonstrated that treatment with poly(ADP-ribose) polymerase (PARP) inhibitors sensitize BRCA1-deficient ovarian cancers to immune checkpoint blockade in preclinical models. The extended survival in response to this combination was associated with a significant… read more here.
Keywords: immunogenic cell; parp inhibition; cell death; cell ... See more keywords
Abstract B032: Combined A2AR and PARP inhibition in homologous recombination deficient (HRD) castrate-resistant prostate cancer (CRPC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b032
Abstract: Background: In response to cellular death and hypoxia, ATP is passively released into the extracellular space. ATP undergoes rapid stepwise conversion to the potent, immune-suppressive adenosine by ectoenzymes CD39 and CD73. Engagement of adenosine with… read more here.
Keywords: tumor; parp inhibition; prostate cancer; cancer ... See more keywords
Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0507-z
Abstract: BackgroundNasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited, novel therapeutic approaches are desperately needed. Here the… read more here.
Keywords: combination; carcinoma; homologous recombination; parp inhibition ... See more keywords
SAT-030 Role of PARP-1 in Regulating Cytokine-Mediated Pro-Inflammatory Transcriptional Responses in Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-030
Abstract: Abstract Macrophages (MF) are major components of the innate immune system involved in mounting inflammatory responses against infection or injury in the host. MF activated by microbial agents, cytokines, or interferon-gamma (IFNg) are highly effective… read more here.
Keywords: inflammatory; parp inhibition; role; pro inflammatory ... See more keywords