The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies
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DOI: 10.1002/cncr.30631
Abstract: As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single‐strand or double‐strand breaks. Loss of function somatic genomic aberrations or germline deficiency in… read more here.
Keywords: parp inhibitors; genitourinary malignancies; homologous recombination; strand ... See more keywords
More breast cancer patients could benefit from PARP inhibitors
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DOI: 10.1002/cncr.30962
Abstract: 3433 CANCER SEPTEMBER 15, 2017 3 Content in this section does not reflect any official policy or medical opinion of the American Cancer Society or of the publisher unless otherwise noted. © American Cancer Society,… read more here.
Keywords: parp inhibitors; brca1 brca2; breast cancer; cancer ... See more keywords
PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside
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DOI: 10.1002/cncr.31307
Abstract: Individuals with breast and ovarian cancer susceptibility gene 1 (BRCA1) or BRCA2 germline mutations have a significantly increased lifetime risk for breast and ovarian cancers. BRCA‐mutant cancer cells have abnormal homologous recombination (HR) repair of… read more here.
Keywords: cancer; parp inhibitors; breast cancer; synthetic lethality ... See more keywords
Strategies Employed for the Development of PARP Inhibitors.
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DOI: 10.1007/978-1-4939-6993-7_18
Abstract: This chapter describes the approaches taken in the development of the first PARP inhibitor to enter clinical trial, rucaparib (now called Rubraca), in 2003. We describe the general principles of crystal-based drug design, the purification… read more here.
Keywords: parp inhibitors; employed development; parp; development parp ... See more keywords
Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting
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DOI: 10.1007/s00262-021-02852-4
Abstract: Rationale exists for combining immune checkpoint inhibitors and PARP inhibitors (PARPi), and results of clinical trials in ovarian cancer are promising, but data in other cancers are limited. Efficacy and safety of PARPi/anti-PD-1 in advanced… read more here.
Keywords: parp inhibitors; solid tumors; advanced solid; efficacy safety ... See more keywords
Design of potential anti-tumor PARP-1 inhibitors by QSAR and molecular modeling studies
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DOI: 10.1007/s11030-020-10063-9
Abstract: Abstract Poly ADP-ribose polymerase-1 (PARP-1) inhibitors have been recognized as new agents for the treatment of patients with breast cancer type 1 (BRCA1) disorders. The quantitative structure–activity relationships (QSAR) technique was used in order to… read more here.
Keywords: parp inhibitors; design potential; potential anti; anti tumor ... See more keywords
Homologous repair deficiencies and current insights in clinical evaluation of PARP inhibitors in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-020-00599-9
Abstract: Homologous repair deficiency is a clinically relevant molecular aberration in prostate cancer. The goal of this short review is to summarize the study landscape of treatments targeting these aberrations through discussion of the most relevant clinical… read more here.
Keywords: parp inhibitors; prostate cancer; cancer; homologous repair ... See more keywords
Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors.
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DOI: 10.1016/j.bioorg.2019.103181
Abstract: Two new series of compounds were designed and synthesized as potent PARP-1 inhibitors. These compounds were evaluated for PARP-1 enzyme and cellular inhibitory activities. All efforts lead to the identification of 9k (named as LG-12)… read more here.
Keywords: parp inhibitors; design synthesis; potent parp; evaluation ... See more keywords
[PARP inhibitors in breast cancer: Current clinical development and perspectives].
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2020.07.011
Abstract: The association of a germline mutation in the BRCA1/2 genes in breast cancer leads to a higher genomic instability and, thus, a potential higher sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. In this review, we will summarize… read more here.
Keywords: parp inhibitors; cancer current; inhibitors breast; breast cancer ... See more keywords
[Recent therapeutic trends in triple-negative metastatic breast cancers: PARP inhibitors, immunotherapies and antibody-drug conjugates].
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2020.11.007
Abstract: Compared with other breast cancer subtypes, patients with metastatic triple-negative breast cancer (TNBC) are younger and have a worst overall survival with a median of 15 to 18 months. These tumors have long suffered from… read more here.
Keywords: parp inhibitors; breast; breast cancers; antibody drug ... See more keywords
[Place of PARP inhibitors in the treatment of endometrial and cervical cancers].
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DOI: 10.1016/j.bulcan.2021.09.011
Abstract: New molecular therapeutic approaches have emerged in recent years for advanced gynaecological cancers, including targeted therapies such as poly-ADP-ribose polymerase inhibitors (PARPi). These have demonstrated efficacy in high-grade serous ovarian cancers in patients carrying a… read more here.
Keywords: parp inhibitors; cervical cancers; endometrial cervical; place parp ... See more keywords