Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1175-x
Abstract: Poly(ADP-ribose)-polymerase (PARP)-1 and PARP-2 play an essential role in the DNA damage response. Based on this effect of PARP in the tumor cell itself, PARP inhibitors have emerged as new therapeutic tools both approved and… read more here.
Keywords: response; deficiency; parp; cell ... See more keywords
PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas
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DOI: 10.1038/srep41962
Abstract: The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficiency of… read more here.
Keywords: cell; immune responses; parp; double deficiency ... See more keywords
Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ"
DOI: 10.7717/peerj.9241
Abstract: Background Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer. An increasing number of studies have focused on the development of highly selective inhibitors… read more here.
Keywords: revealing selective; mechanisms inhibitors; parp; inhibitors parp ... See more keywords