Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
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DOI: 10.1016/j.ccell.2019.05.001
Abstract: We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates… read more here.
Keywords: toxicity; therapy; parp wee1; wee1 inhibitors ... See more keywords