XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71203-7
Abstract: Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in… read more here.
Keywords: xrn2; parp1 inhibition; repair; dna ... See more keywords
PARP1 inhibition elicits immune responses against non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2111915
Abstract: ABSTRACT High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation… read more here.
Keywords: small cell; parp1 inhibition; non small; cell lung ... See more keywords
PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000546
Abstract: INTRODUCTION Burn injury induces multiple signaling pathways leading to a significant inflammatory storm that adversely affects multiple organs, including the heart. PARP1 inhibition, with specific agents such as PJ34, is effective in reducing oxidative stress… read more here.
Keywords: cardiac function; burn injury; parp1 inhibition; injury induced ... See more keywords