PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109695
Abstract: The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an intrinsic driver for oligodendroglial development and myelination. Genetic PARP1… read more here.
Keywords: parp1 mediated; myelination; parylation; differentiation ... See more keywords
Role of PARP1-mediated autophagy in EGFR-TKI resistance in non-small cell lung cancer
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DOI: 10.1038/s41598-020-77908-z
Abstract: Resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1-mediated autophagy in the progression of TKI therapy.… read more here.
Keywords: mediated autophagy; role parp1; parp1 mediated; resistance ... See more keywords