In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers
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DOI: 10.3390/molecules28041829
Abstract: The protein PARP1, which plays a crucial role in DNA repair processes, is an attractive target for cancer therapy, especially for BRCA-deficient cancers. To overcome the acquired drug resistance of PARP1, PARP1 G-quadruplex (G4) identified… read more here.
Keywords: parp1 parp1; brca deficient; deficient cancers; parp1 ... See more keywords