Impact of PARP1, PARP2 & PARP3 on the Base Excision Repair of Nucleosomal DNA.
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DOI: 10.1007/978-3-030-41283-8_4
Abstract: DNA is constantly attacked by different damaging agents; therefore, it requires frequent repair. On the one hand, the base excision repair (BER) system is responsible for the repair of the most frequent DNA lesions. On… read more here.
Keywords: parp1 parp2; base excision; dna; excision repair ... See more keywords
A Single-Molecule Atomic Force Microscopy Study of PARP1 and PARP2 Recognition of Base Excision Repair DNA Intermediates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.05.028
Abstract: Nuclear poly(ADP-ribose) polymerases 1 and 2 (PARP1 and PARP2) catalyze the synthesis of poly(ADP-ribose) (PAR) and use NAD+ as a substrate for the polymer synthesis. Both PARP1 and PARP2 are involved in DNA damage response… read more here.
Keywords: parp1 parp2; dna; microscopy; parp1 ... See more keywords
Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214209120
Abstract: Significance PARP [Poly(ADP-ribose) polymerase] proteins are important signaling enzymes in eukaryotic DNA damage repair. We investigated how PARP1 and PARP2 bind at DNA double-strand breaks (DSBs) by developing a single-molecule magnetic tweezers assay to measure… read more here.
Keywords: dna; parp1 parp2; spectroscopy; dna double ... See more keywords
Abstract 6111: Design of a small molecule screening assay to detect DNA trapping of PARP1/2
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6111
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors are currently used in the clinic for the treatment of tumors with a defective DNA damage response (DDR). When PARP1 or PARP2 binds damaged DNA, it adds poly(ADP-ribose) chains to its… read more here.
Keywords: dna; parp1 parp2; dna trapping; parp1 ... See more keywords
Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
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DOI: 10.1186/s12885-020-06903-4
Abstract: Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many… read more here.
Keywords: parp1 parp2; trpm2; expression; acute myeloid ... See more keywords