PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors
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DOI: 10.1093/nar/gkae756
Abstract: Abstract PARP inhibitors (PARPi) show selective efficacy in tumors with homologous recombination repair (HRR)-defects but the activation mechanism of HRR pathway in PARPi-treated cells remains enigmatic. To unveil it, we searched for the mediator bridging… read more here.
Keywords: parp inhibitors; mrn complex; mrn; parp1 trim44 ... See more keywords