RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12132
Abstract: Dear editor, ADP-ribosylation is a post-translational modification catalysed by poly(ADP-ribose) polymerases (PARPs) and plays important roles in diverse biological processes, such as DNA repair, chromatin remodelling, telomere homeostasis, transcription, chromosome segregation, cell proliferation, and cell… read more here.
Keywords: rnf114; tumor; metastasis; cancer ... See more keywords
PARP10 suppresses tumor metastasis through regulation of Aurora A activity
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DOI: 10.1038/s41388-018-0168-5
Abstract: ADP-ribosylation, including poly-ADP-ribosylation (PARylation) and mono-ADP-ribosylation (MARylation), is a multifunctional post-translational modification catalyzed by intracellular ADP-ribosyltransferases (ARTDs or PARPs). Although PARylation has been investigated most thoroughly, the function of MARylation is currently largely undefined. Here,… read more here.
Keywords: aurora activity; regulation aurora; tumor metastasis; parp10 ... See more keywords
Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival
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DOI: 10.18632/oncotarget.28277
Abstract: PARP10 is a mono-ADP-ribosyltransferase with multiple cellular functions, including proliferation, apoptosis, metabolism and DNA repair. PARP10 is overexpressed in a significant proportion of tumors, particularly breast and ovarian cancers. Identifying genetic susceptibilities based on PARP10… read more here.
Keywords: genome wide; mediated cellular; parp10; parp10 mediated ... See more keywords
PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215210
Abstract: Simple Summary Mono-ADP-ribosylating PARP enzymes are involved in the regulation of several cellular pathways, including cell cycle. The mono-ADP-ribosyltransferase PARP10 is frequently amplified in different tumor types, and has been shown to promote in vitro… read more here.
Keywords: parp10; transition; mono adp; cell cycle ... See more keywords