PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
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DOI: 10.1038/s41467-018-05588-5
Abstract: Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification involved in multiple biological processes, including DNA damage repair. This modification is catalyzed by poly(ADP-ribose) polymerase (PARP) family of enzymes. PARylation is composed of both linear and branched polymers… read more here.
Keywords: dna damage; par; poly adp; response ... See more keywords
miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2
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DOI: 10.1042/bsr20180890
Abstract: The present study aimed to explore miR-125 effects on rheumatoid arthritis (RA) development to provide a potential target for RA. Briefly, rat RA model was established (Model group) by injection of Freund’s Complete Adjuvant into… read more here.
Keywords: parp2; mir 125; pi3k akt; group ... See more keywords
Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging.
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DOI: 10.1042/bst20220366
Abstract: Poly (ADP-ribose) polymerase-1 (PARP1) and 2 (PARP2) are two DNA damage-induced poly (ADP-ribose) (PAR) polymerases in cells and are the targets of PARP inhibitors used for cancer therapy. Strand breaks recruit and activate PARP1 and… read more here.
Keywords: quantitative live; cell imaging; parp2; parp1 ... See more keywords
PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites
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DOI: 10.1093/nar/gkac188
Abstract: Abstract Dual-inhibitors of PARP1 and PARP2 are promising anti-cancer drugs. In addition to blocking PARP1&2 enzymatic activity, PARP inhibitors also extend the lifetime of DNA damage-induced PARP1&2 foci, termed trapping. Trapping is important for the… read more here.
Keywords: parp2 dna; dna damage; parp2; parp inhibitors ... See more keywords