PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites
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DOI: 10.1093/nar/gkac188
Abstract: Abstract Dual-inhibitors of PARP1 and PARP2 are promising anti-cancer drugs. In addition to blocking PARP1&2 enzymatic activity, PARP inhibitors also extend the lifetime of DNA damage-induced PARP1&2 foci, termed trapping. Trapping is important for the… read more here.
Keywords: parp2 dna; dna damage; parp2; parp inhibitors ... See more keywords