PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines
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DOI: 10.1007/s10549-018-4888-6
Abstract: PurposePARP-3 is member of the PARP family of poly (ADP-ribose) polymerases involved in ADPribosylation. PARPs are involved in the basic mechanisms of DNA repair. PARP3, a critical player for efficient mitotic progression, is required for… read more here.
Keywords: parp3; vinorelbine; parp3 inhibitors; breast cancer ... See more keywords
The Development of a Biotinylated NAD+-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay
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DOI: 10.1177/2472555218767843
Abstract: Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. The biological roles of PARP3 are currently under investigation; however, several key reports… read more here.
Keywords: poly adp; biotinylated nad; ribose polymerase; parp3 ... See more keywords
PARP3 Promotes AML Progression via Activation of PI3K/AKT/mTOR Signaling
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DOI: 10.3390/cancers17183076
Abstract: Simple Summary Acute myeloid leukemia (AML) remains an incurable malignant tumor that constitutes a major threat to human health. Refractory and relapsed cases remain two major causes of treatment failure. Therefore, there is an urgent… read more here.
Keywords: expression; akt mtor; parp3; pi3k akt ... See more keywords