Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2021.04.010
Abstract: Histone eviction and chromatin relaxation are important processes for efficient DNA repair. Poly(ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and disruption of PARP1 activity has a direct impact on… read more here.
Keywords: chromatin remodeling; chromatin; par dependent; studying par ... See more keywords
Construction of PARPi Resistance-related Competing Endogenous RNA Network
Sign Up to like & getrecommendations! Published in 2022 at "Current Genomics"
DOI: 10.2174/1389202923666220527114108
Abstract: Objective: Ovarian cancer is a kind of common gynecological malignancy in women. PARP inhibitors (PARPi) have been approved for ovarian cancer treatment. However, the primary and acquired resistance have limited the application of PARPi. The… read more here.
Keywords: ovarian cancer; resistance; signaling pathway; parpi resistance ... See more keywords