Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29311
Abstract: Susceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated… read more here.
Keywords: magnetic resonance; pars compacta; nigra pars; resonance imaging ... See more keywords
Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.11.016
Abstract: Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here,… read more here.
Keywords: pars compacta; nigra pars; locus coeruleus; substantia nigra ... See more keywords
Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.682067
Abstract: The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the… read more here.
Keywords: pars compacta; nigra pars; compacta ventral; substantia nigra ... See more keywords
Evidence That Substantia Nigra Pars Compacta Dopaminergic Neurons Are Selectively Vulnerable to Oxidative Stress Because They Are Highly Metabolically Active
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.826193
Abstract: There are 400–500 thousand dopaminergic cells within each side of the human substantia nigra pars compacta (SNpc) making them a minuscule portion of total brain mass. These tiny clusters of cells have an outsized impact… read more here.
Keywords: stress; pars compacta; nigra pars; substantia nigra ... See more keywords
Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092278
Abstract: Parkinson’s disease (PD) is one of the key neurodegenerative disorders caused by a dopamine deficiency in the striatum due to the death of dopaminergic (DA) neurons of the substantia nigra pars compacta. The initially discovered… read more here.
Keywords: pars compacta; nigra pars; substantia nigra; synuclein ... See more keywords
Vitamin D3 promotes oligodendrogenesis and modulates synucleinopathy in lead-induced nigral Pars Compacta neurotoxicity in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Folia morphologica"
DOI: 10.5603/fm.a2022.0003
Abstract: BACKGROUND Lead-induced neurotoxicity was marked with Locomotor and parkinsonian-like changes. Oligodendrocytes and synucleinopathy were signed to in the pathophysiology of some neurodegenerative diseases. Vitamin D3's (D3) role in substantia nigra pars compacta (SNpc) disorders is… read more here.
Keywords: pars compacta; promotes oligodendrogenesis; vitamin promotes; lead induced ... See more keywords