Association of Beneficiary-Level Risk Factors and Hospital-Level Characteristics With Medicare Part B Drug Spending Differences Between 340B and Non-340B Hospitals
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.0045
Abstract: Key Points Question Is per-beneficiary Medicare Part B drug spending significantly different at hospitals that are part of the federal 340B Drug Pricing Program, which can purchase outpatient drugs from manufacturers at discounted prices, compared… read more here.
Keywords: medicare part; part drug; level; drug spending ... See more keywords
Analysis of Anti-Vascular Endothelial Growth Factor Injection Claims Data in US Medicare Part B Beneficiaries From 2012 to 2015.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2019.1971
Abstract: Importance The frequency of anti-vascular endothelial growth factor (VEGF) injections has grown exponentially with the introduction of bevacizumab, ranibizumab, and most recently aflibercept. The cost associated with these medications has garnered significant national attention, warranting… read more here.
Keywords: part beneficiaries; bevacizumab; part; 2012 2015 ... See more keywords
Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26529
Abstract: Natural killer (NK) cells are part of a phylogenetically old defense system, which is characterized by its strong cytolytic function against physiologically stressed cells such as tumor cells and virus‐infected cells. Their use in the… read more here.
Keywords: system; natural killer; killer cells; hematological malignancies ... See more keywords
The impact of industry and body part injured on repeat workers' compensation claims.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of industrial medicine"
DOI: 10.1002/ajim.22994
Abstract: BACKGROUND Few studies investigate the influence of body part injured and industry on future workers' compensation claims. METHODS Using claims incurred from 1 January 2005 to 31 July 2015 (n = 77 494) from the largest workers' compensation insurer… read more here.
Keywords: part; industry; workers compensation; body part ... See more keywords
Debating Eukaryogenesis—Part 2: How Anachronistic Reasoning Can Lure Us into Inventing Intermediates
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.201900153
Abstract: Eukaryotic origins are inextricably linked with the arrival of a pre‐mitochondrion of alphaproteobacterial‐like ancestry. However, the nature of the “host” cell and the mode of entry are subject to heavy debate. It is becoming clear… read more here.
Keywords: part; debating eukaryogenesis; eukaryogenesis part; part anachronistic ... See more keywords
“Why Anatomy is neglected or mistaught”
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Anatomy"
DOI: 10.1002/ca.22991
Abstract: In Galen’s De Anatomicis Administrationibus (On Anatomical Procedures) (Singer, 1956), written in Rome in the year A.D. 177, Book II (On Muscles and Ligaments of the Lower Limb), Chapter 3 is intriguingly titled “Why Anatomy… read more here.
Keywords: anatomy neglected; part; neglected mistaught; anatomy ... See more keywords
Parcellation of the murine cortical hindlimb area is demonstrated by its subcortical connectivity and cytoarchitecture
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25313
Abstract: Although corticospinal neurons are known to be distributed in both the primary motor and somatosensory cortices (S1), details of the projection pattern of their fibers to the lumbar cord gray matter remain largely uncharacterized, especially… read more here.
Keywords: area; part; gray matter; lumbar cord ... See more keywords
Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1051
Abstract: GSK3640254 is a next-generation maturation inhibitor with demonstrated potency across HIV-1 subtypes and a high barrier to emergent resistance. This phase I, 2-part, randomized, open-label study (ClinicalTrials.gov identifier, NCT04263142) in healthy participants assessed the relative… read more here.
Keywords: food; gsk3640254; healthy participants; part ... See more keywords
A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1224
Abstract: Savolitinib is an oral MET (hepatocyte growth factor receptor) tyrosine kinase inhibitor, with demonstrated preliminary efficacy in several cancer types. Previous pharmacokinetics assessments showed that savolitinib is rapidly absorbed but there are limited data on… read more here.
Keywords: metabolism; bioavailability; savolitinib; bioavailability absorption ... See more keywords
Comparison of Two Manufacturing Processes of Daprodustat for Bioequivalence and Dissolution in Healthy Volunteers: A Randomized Crossover Study.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1257
Abstract: Daprodustat, an orally bioavailable hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitor, has recently completed phase 3 clinical development for treating anemia of chronic kidney disease. Part A of this 2-part, randomized, double-blind, single-dose, cross-over study (NCT04640311) compared… read more here.
Keywords: tablets manufactured; dissolution; bioequivalence; manufacturing processes ... See more keywords
Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.957
Abstract: This phase 1, 2-part, 2-period, open-label, drug-drug interaction study evaluated the potential for pharmacokinetic interactions between upadacitinib and rosuvastatin, an organic anion transporting polypeptide (OATP) 1B1 and breast cancer resistance protein substrate, or atorvastatin, a… read more here.
Keywords: effect upadacitinib; part; pharmacokinetics rosuvastatin; effect ... See more keywords