Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2020.11.055
Abstract: Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes.1 Although detyrosination is the oldest known microtubule PTM,2-7 the carboxypeptidase responsible for this modification, VASH1/2-SVBP,… read more here.
Keywords: parthenolide; vash1 svbp; tubulin; parthenolide destabilizes ... See more keywords
Hsp72 Is an Intracellular Target of the α,β-Unsaturated Sesquiterpene Lactone, Parthenolide
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b00954
Abstract: The electrophilic natural product parthenolide has generated significant interest as a model for potential chemotherapeutics. Similar to other α,β-unsaturated carbonyl electrophiles, parthenolide induces the heat shock response in leukemia cells, potentially through covalent adduction of… read more here.
Keywords: heat shock; parthenolide; parthenolide derivative; hsp72 ... See more keywords
Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00132
Abstract: Parthenolide, a kind of sesquiterpene lactone, is the direct precursor for the promising anti-glioblastoma drug ACT001. Compared with traditional parthenolide source from plant extraction, de novo biosynthesis of parthenolide in microorganisms has the potential to… read more here.
Keywords: production plant; parthenolide; sesquiterpene lactone; plant ... See more keywords
Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.592
Abstract: Abstract Funding Acknowledgements Type of funding sources: None. Background The cardiac sodium channel Nav1.5 is transported to the membrane by the microtubule network. Alterations in microtubule dynamics are known to impact on ion channel trafficking.… read more here.
Keywords: microtubule detyrosination; parthenolide; mdx; cms ... See more keywords
Parthenolide inhibits the growth of non-small cell lung cancer by targeting epidermal growth factor receptor
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01658-1
Abstract: Background EGFR tyrosine kinase inhibitors (TKIs) have been developed for the treatment of EGFR mutated NSCLC. Parthenolide, a natural product of parthenolide, which belongs to the sesquiterpene lactone family and has a variety of biological… read more here.
Keywords: egfr; parthenolide; cell; pharmacology ... See more keywords