The atypical KRAS Q22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.70014
Abstract: Transforming growth factor beta (TGF‐β) exhibits complex and context‐dependent cellular responses. While it mostly induces tumor‐suppressive effects in early stages of tumorigenesis, tumor‐promoting properties are evident in advanced disease. This TGF‐β duality is still not… read more here.
Keywords: colorectal cancer; cancer; patient derived; partial epithelial ... See more keywords
HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation
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DOI: 10.1038/s41420-025-02799-w
Abstract: In mammalian reproduction, a significant proportion of embryos fail to implant despite a receptive uterus, suggesting that defects in epithelial remodelling at the embryo-uterine interface contribute to implantation failure. The molecular programs enabling such remodelling… read more here.
Keywords: mesenchymal transition; hoxa10; hoxa10 twist2; partial epithelial ... See more keywords
Comprehensive analysis of partial epithelial mesenchymal transition‐related genes in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16099
Abstract: Increasing evidence has revealed that cancer cells undergoing an intermediate state, partial epithelial mesenchymal transition (p‐EMT), tend to metastasize rather than complete EMT. We performed a comprehensive analysis of E‐cadherin and 25 p‐EMT‐related genes in… read more here.
Keywords: emt related; mesenchymal transition; analysis; epithelial mesenchymal ... See more keywords