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   Articles with "partial lipodystrophy" as a keyword



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Update on Therapeutic Options in Lipodystrophy

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recommendations! Published in 2018 at "Current Diabetes Reports"

DOI: 10.1007/s11892-018-1100-7

Abstract: Purpose of ReviewThe purpose of this review is to summarize the therapeutic approach for lipodystrophy syndromes with conventional treatment options and metreleptin therapy in detail and to point out the current investigational treatments in development.Recent… read more here.

Keywords: therapeutic options; options lipodystrophy; update therapeutic; treatment ... See more keywords
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Clinical characteristics in two patients with partial lipodystrophy and Type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene.

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recommendations! Published in 2019 at "Diabetes research and clinical practice"

DOI: 10.1016/j.diabres.2019.04.034

Abstract: AIMS The present report aimed to clarify the clinical characteristics in a girl at the age of 12 and her mother with partial lipodystrophy and Type A insulin resistance syndrome. METHODS We examined fat distribution… read more here.

Keywords: insulin; insulin receptor; lipodystrophy; insulin resistance ... See more keywords
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Familial partial lipodystrophy syndromes.

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recommendations! Published in 2021 at "Presse medicale"

DOI: 10.1016/j.lpm.2021.104071

Abstract: Lipodystrophies are a heterogeneous group of rare conditions characterised by the loss of adipose tissue. The most common forms are familial partial lipodystrophy (FPLD) syndromes, which include a set of disorders, usually autosomal dominant, due… read more here.

Keywords: familial partial; lipodystrophy syndromes; lipodystrophy; fpld ... See more keywords
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Acquired partial lipodystrophy and C3 glomerulopathy: Dysregulation of the complement system as a common mechanism

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recommendations! Published in 2018 at "Nefrologia"

DOI: 10.1016/j.nefroe.2018.04.002

Abstract: The activation of the alternative pathway of the complement is involved in the development of several renal diseases, such as atypical haemolytic uremic syndrome and C3 glomerulopathy. In C3 glomerulopathy, a high percentage of patients… read more here.

Keywords: complement; acquired partial; complement system; partial lipodystrophy ... See more keywords
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Polycystic ovary syndrome in familial partial lipodystrophy type 2 (FPLD2): basic and clinical aspects

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recommendations! Published in 2018 at "Nucleus"

DOI: 10.1080/19491034.2018.1509659

Abstract: ABSTRACT Polycystic ovary syndrome (PCOS) is a common disorder with a high phenotypic variability. Frequently, it is associated with a mild to moderate insulin resistance (IR) caused by an interaction between polygenic diathesis and the… read more here.

Keywords: polycystic ovary; familial partial; lipodystrophy; ovary syndrome ... See more keywords

Phenotypic diversity and glucocorticoid sensitivity in patients with familial partial lipodystrophy type 2

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recommendations! Published in 2019 at "Clinical Endocrinology"

DOI: 10.1111/cen.13984

Abstract: Familial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities and central obesity. Due to the resemblance with Cushing's syndrome, we hypothesized a putative role of glucocorticoid in the… read more here.

Keywords: partial lipodystrophy; familial partial; lipodystrophy type; phenotypic diversity ... See more keywords
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Autoimmune hepatitis and acquired partial lipodystrophy

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recommendations! Published in 2021 at "Frontline Gastroenterology"

DOI: 10.1136/flgastro-2021-101824

Abstract: The lipodystrophies are an extremely rare group of metabolic conditions which are categorised based on their pathogenesis and phenotype. While primarily known for the striking loss of subcutaneous adipose tissue which they induce, they may… read more here.

Keywords: autoimmune hepatitis; partial lipodystrophy; acquired partial; lipodystrophy ... See more keywords
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P03 A curious case of autoimmune hepatitis and acquired partial lipodystrophy

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recommendations! Published in 2021 at "Frontline Gastroenterology"

DOI: 10.1136/flgastro-2021-bspghan.14

Abstract: Background The lipodystrophies are an extremely rare group of metabolic conditions. In acquired partial lipodystrophy (APL), the predominant clinical feature is a progressive, symmetrical reduction of adipose tissue which typically begins during the pre-adolescent period.… read more here.

Keywords: hepatitis; partial lipodystrophy; acquired partial; autoimmune hepatitis ... See more keywords
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Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study

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recommendations! Published in 2021 at "Lipids in Health and Disease"

DOI: 10.1186/s12944-021-01589-4

Abstract: Background Familial partial lipodystrophy (FPLD) is a rare disease characterized by selective loss of peripheral subcutaneous fat, associated with dyslipidemia and diabetes mellitus. Reductions in circulating levels of ANGPTL3 are associated with lower triglyceride and… read more here.

Keywords: partial lipodystrophy; angptl3 vupanorsen; treatment; familial partial ... See more keywords
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Inhibition of Angiopoietin-Like 3 (ANGPTL3) Reduces Adipose Tissue Insulin Resistance in Patients With Familial Partial Lipodystrophy

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recommendations! Published in 2021 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvab048.100

Abstract: Abstract Familial partial lipodystrophy (FPLD) is a rare disease characterized by selective loss of peripheral subcutaneous fat, usually affecting the trunk and limbs, but preservation in other areas, such as the face and neck. It… read more here.

Keywords: patients fpld; tissue insulin; angptl3; familial partial ... See more keywords
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Phenotypic Differences Among Familial Partial Lipodystrophy Due to LMNA or PPARG Variants

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recommendations! Published in 2022 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvac155

Abstract: Abstract Context Despite several reports of familial partial lipodystrophy (FPLD) type 2 (FPLD2) due to heterozygous LMNA variants and FPLD3 due to PPARG variants, the phenotypic differences among them remain unclear. Objective To compare the… read more here.

Keywords: familial partial; partial lipodystrophy; phenotypic differences; lipodystrophy ... See more keywords