PND43 THE BURDEN OF PEDIATRIC PARTIAL ONSET SEIZURES: A REVIEW OF THE LITERATURE
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DOI: 10.1016/j.jval.2019.04.1316
Abstract: CONCLUSIONS • To better understand the burden of epilepsy among 2to 12year-olds, we conducted a targeted literature review summarizing humanistic and economic outcomes. Data specific to POS are presented here. • Using MeSH and text… read more here.
Keywords: pediatric partial; onset seizures; partial onset; pnd43 burden ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures
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DOI: 10.1111/ane.12874
Abstract: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS) and identify factors explaining between‐subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. read more here.
Keywords: partial onset; perampanel; pharmacodynamic analysis; onset seizures ... See more keywords
Adjunctive perampanel in partial‐onset seizures: Asia‐Pacific, randomized phase III study
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DOI: 10.1111/ane.12883
Abstract: To evaluate the efficacy, safety, and tolerability of perampanel, a selective, non‐competitive, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, as an adjunctive treatment for patients with refractory partial‐onset seizures (POS) from Asia‐Pacific. read more here.
Keywords: asia pacific; adjunctive perampanel; partial onset; onset seizures ... See more keywords
New developments in the management of partial-onset epilepsy: role of brivaracetam
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DOI: 10.2147/dddt.s103468
Abstract: Currently, a number of novel anticonvulsant drugs, the so-called third generation, are in various stages of development. Several of them are already available or in ongoing clinical trials. These new compounds should take advantage of… read more here.
Keywords: brivaracetam; partial onset; drug; anticonvulsant drugs ... See more keywords
Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABAA Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications
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DOI: 10.3390/neurolint13020026
Abstract: Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment.… read more here.
Keywords: allosteric modulator; partial onset; modulator gabaa; gabaa ion ... See more keywords