Partial Reprogramming as a Method for Regenerating Neural Tissues in Aged Organisms
Sign Up to like & getrecommendations! Published in 2024 at "Cellular Reprogramming"
DOI: 10.1089/cell.2023.0123
Abstract: Aging causes numerous age-related diseases, leading the human species to death. Nevertheless, rejuvenating strategies based on cell epigenetic modifications are a possible approach to counteract disease progression while getting old. Cell reprogramming of adult somatic… read more here.
Keywords: reprogramming; reprogramming method; age related; cell ... See more keywords
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging
Sign Up to like & getrecommendations! Published in 2024 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adg1777
Abstract: Aging is a complex multifactorial process associated with epigenome dysregulation, increased cellular senescence, and decreased rejuvenation capacity. Short-term cyclic expression of octamer-binding transcription factor 4 (Oct4), sex-determining region Y-box 2 (Sox2), Kruppel-like factor 4 (Klf4),… read more here.
Keywords: mice; cdkn2a; cell; expression ... See more keywords
Long Live Partial Reprogramming.
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/circresaha.117.310594
Abstract: In vivo amelioration of age-associated hallmarks by partial reprogramming . Ocampo et al Cell. 2016;167:1719–1733. Aging can be defined as the progressive loss of physiological integrity that leads to tissue dysfunction and increased risk for… read more here.
Keywords: partial reprogramming; live partial; long live; age associated ... See more keywords