C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
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DOI: 10.1016/j.yjmcc.2019.03.024
Abstract: The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic peptide (CNP), induces anti-remodeling actions in the heart and kidney through the generation of the second messenger 3', 5' cyclic guanosine monophosphate (cGMP). Indeed… read more here.
Keywords: anti fibrotic; activator; guanylyl cyclase; particulate guanylyl ... See more keywords