Development of parvalbumin neurons and perineuronal nets in the visual cortex of normal and dark‐exposed cats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25127
Abstract: During development, the visual system maintains a high capacity for modification by expressing characteristics permissive for plasticity, enabling neural circuits to be refined by visual experience to achieve their mature form. This period is followed… read more here.
Keywords: parvalbumin; plasticity; development; perineuronal nets ... See more keywords
Axonal sprouting in commissurally projecting parvalbumin‐expressing interneurons
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24011
Abstract: Previous research has shown that in vivo on‐demand optogenetic stimulation of inhibitory interneurons expressing parvalbumin (PV) is sufficient to suppress seizures in a mouse model of temporal lobe epilepsy (TLE). Surprisingly, this intervention was capable… read more here.
Keywords: expressing interneurons; commissurally projecting; axonal sprouting; parvalbumin ... See more keywords
Acute neuroinflammation increases excitability of prefrontal parvalbumin interneurons and their functional recruitment during novel object recognition
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.08.216
Abstract: There is an emerging body of literature suggesting that unlike the chronic neuroinflammatory response, acute neuroinflammation is self-regulated and is beneficial for central nervous system homeostasis and cognitive integrity. However, the neurophysiological alterations upon acute… read more here.
Keywords: acute neuroinflammation; object recognition; neuroinflammation; parvalbumin ... See more keywords
Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109087
Abstract: Summary Parvalbumin (PV) is a cytosolic Ca2+-binding protein highly expressed in fast skeletal muscle, contributing to an increased relaxation rate. Moreover, PV is an “atrogene” downregulated in most muscle atrophy conditions. Here, we exploit mice… read more here.
Keywords: skeletal muscle; muscle; mitochondrial calcium; hypertrophy ... See more keywords
Investigating the role of dopamine receptor- and parvalbumin-expressing cells in extinction of conditioned fear
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.08.009
Abstract: HighlightsExtinction increased Fos+ and decreased D2R+ cells in the infralimbic cortex.Fear retrieval increased Fos labeling of D2R+ cells in the prelimbic cortex.Context exposure, retrieval, and extinction display overlapping neural activation. ABSTRACT The present study examined… read more here.
Keywords: memory; retrieval; extinction; parvalbumin ... See more keywords
Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0709-9
Abstract: The expression of the calcium binding protein parvalbumin (PV) has been observed in several cortical regions during development in a temporal pattern consistent with increased afferent-dependent activity. In the prefrontal cortex (PFC), PV expression appears… read more here.
Keywords: adolescence; gabaergic; expression; parvalbumin ... See more keywords
Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa413
Abstract: Many developmental syndromes have been linked to genetic mutations that cause abnormal ERK/MAPK activity; however, the neuropathological effects of hyperactive signaling are not fully understood. Here, we examined whether hyperactivation of MEK1 modifies the development… read more here.
Keywords: hyperactive mek1; mek1 signaling; neuron; parvalbumin ... See more keywords
Neonatal Ethanol Disturbs the Normal Maturation of Parvalbumin Interneurons Surrounded by Subsets of Perineuronal Nets in the Cerebral Cortex: Partial Reversal by Lithium
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhy034
Abstract: Reduction in parvalbumin-positive (PV+) interneurons is observed in adult mice exposed to ethanol at postnatal day 7 (P7), a late gestation fetal alcohol spectrum disorder model. To evaluate whether PV+ cells are lost, or PV… read more here.
Keywords: cell density; cerebral cortex; parvalbumin; pnn ... See more keywords
Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Integrative Neuroscience"
DOI: 10.3389/fnint.2022.765324
Abstract: Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an essential role in regulating many physiological processes, such as intracellular signaling and synaptic transmission. Changes in parvalbumin expression are deeply related to epilepsy,… read more here.
Keywords: parvalbumin; intervention; role; epilepsy psychiatric ... See more keywords
Oncomodulin: The Enigmatic Parvalbumin Protein
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00235
Abstract: EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin. Herein, we provide an… read more here.
Keywords: protein; parvalbumin protein; enigmatic parvalbumin; ca2 ... See more keywords
Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.80324
Abstract: In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable sensitive… read more here.
Keywords: function; period; activity; parvalbumin ... See more keywords