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   Articles with "parvalbumin expressing" as a keyword



Every-Other-Day Feeding Prevents the Loss of Parvalbumin-Expressing Neurons in the Cerebral Cortex of Female 5xFAD Mice

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recommendations! Published in 2025 at "Molecular Neurobiology"

DOI: 10.1007/s12035-025-05355-w

Abstract: The present study demonstrates the effects of an every-other-day (EOD) feeding regimen on parvalbumin (PV)-expressing interneurons in the cortex of 5xFAD mice, a well-established animal model of Alzheimer’s disease (AD). Female 5xFAD mice and their… read more here.

Keywords: 5xfad mice; loss; eod feeding; parvalbumin expressing ... See more keywords

Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.107829

Abstract: Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and… read more here.

Keywords: expressing interneurons; striatal parvalbumin; parvalbumin expressing; medium spiny ... See more keywords

Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-13533-3

Abstract: Fast-spiking parvalbumin-expressing interneurons (PVIs) and granule cells (GCs) of the dentate gyrus receive layer-specific dendritic inhibition. Its impact on PVI and GC excitability is, however, unknown. By applying whole-cell recordings, GABA uncaging and single-cell-modeling, we… read more here.

Keywords: expressing interneurons; inhibition; parvalbumin expressing; dendritic inhibition ... See more keywords

Intersectional strategy to study cortical inhibitory parvalbumin-expressing interneurons

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-52901-y

Abstract: Parvalbumin-expressing (PV) interneurons are key neuronal elements to a global excitatory-inhibitory balance in normal cortical functioning. To better understand the circuit functions of PV interneurons, reliable animal models are needed. This study investigated the sensitivity… read more here.

Keywords: tdtomato; parvalbumin expressing; expressing interneurons; cre ... See more keywords

Fragile X cortex is characterized by decreased parvalbumin-expressing interneurons.

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recommendations! Published in 2024 at "Cerebral cortex"

DOI: 10.1093/cercor/bhae103

Abstract: Fragile X syndrome is a genetic neurodevelopmental disorder caused by a mutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene in the X chromosome. Many fragile X syndrome cases present with autism spectrum disorder… read more here.

Keywords: disorder; parvalbumin expressing; expressing interneurons; fragile syndrome ... See more keywords

Conditional Deletion of CB1 Receptor in Parvalbumin‐Expressing GABAergic Neurons Results in Hearing Loss and Abnormal Auditory Brainstem Response in Mice

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recommendations! Published in 2025 at "European Journal of Neuroscience"

DOI: 10.1111/ejn.70069

Abstract: Cannabinoid receptors 1 (CB1Rs) are widely expressed throughout the central auditory system and play important roles in synaptic plasticity, auditory function, and development. However, the specific functions of CB1Rs in distinct neuronal subtypes in the… read more here.

Keywords: auditory brainstem; auditory; deletion; parvalbumin expressing ... See more keywords

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

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recommendations! Published in 2025 at "Epilepsia"

DOI: 10.1111/epi.18532

Abstract: Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have… read more here.

Keywords: expressing inhibitory; dravet syndrome; medial septum; parvalbumin expressing ... See more keywords

Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/8469756

Abstract: Neonatal brain injury is often caused by preterm birth. Brain development is vulnerable to increased environmental stress, including oxidative stress challenges. Due to a premature change of the fetal living environment from low oxygen in… read more here.

Keywords: stress; parvalbumin expressing; oxidative stress; brain ... See more keywords

Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex

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recommendations! Published in 2024 at "eNeuro"

DOI: 10.1523/eneuro.0314-23.2024

Abstract: Canonically, action potentials of most mammalian neurons initiate at the axon initial segment (AIS) and propagate bidirectionally: orthodromically along the distal axon and retrogradely into the soma and dendrites. Under some circumstances, action potentials may… read more here.

Keywords: activity dependent; parvalbumin expressing; expressing interneurons; ectopic spiking ... See more keywords