Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0496-19.2020
Abstract: Abstract Altered cortical excitation-inhibition (E-I) balance resulting from abnormal parvalbumin interneuron (PV IN) function is a proposed pathophysiological mechanism of schizophrenia and other major psychiatric disorders. Preclinical studies have indicated that disrupted-in-schizophrenia-1 (Disc1) is a… read more here.
Keywords: locus impairment; biology; disc1; disc1 locus ... See more keywords
ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00020
Abstract: ProNGF, the precursor of mature Nerve Growth Factor (NGF), is the most abundant NGF form in the brain and increases markedly in the cortex in Alzheimer's Disease (AD), relative to mature NGF. A large body… read more here.
Keywords: prongf; interneuron perineuronal; tgprongf mice; parvalbumin interneuron ... See more keywords
Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.80324
Abstract: In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable sensitive… read more here.
Keywords: function; period; activity; parvalbumin ... See more keywords