A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.10.006
Abstract: The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to… read more here.
Keywords: parvalbumin interneurons; glun2a containing; lack glun2a; glun2a ... See more keywords
Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: relevance for schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-019-0436-3
Abstract: Dysfunction of prefrontal parvalbumin (PV+) interneurons has been linked with severe cognitive deficits as observed in several neurodevelopmental disorders including schizophrenia. However, whether a specific aspect of PV+ neurons deregulation, or a specific molecular mechanism… read more here.
Keywords: schizophrenia; cognitive deficits; nmda receptor; parvalbumin interneurons ... See more keywords
Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI.
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy139
Abstract: Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been… read more here.
Keywords: parvalbumin interneurons; inhibition; tbi; principal neurons ... See more keywords
Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons
Sign Up to like & getrecommendations! Published in 2023 at "eNeuro"
DOI: 10.1523/eneuro.0392-22.2023
Abstract: Abstract Allopregnanolone (AlloP) is a neurosteroid that potentiates ionotropic GABAergic (GABAA) inhibition and is approved for treating postpartum depression in women. Although the antidepressant mechanism of AlloP is largely unknown, it could involve selective action… read more here.
Keywords: inhibition; allopregnanolone effects; effects inhibition; parvalbumin interneurons ... See more keywords
Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1010152
Abstract: Social isolation during the juvenile stage results in structural and functional impairment of the brain and deviant adult aggression. However, the specific subregions and cell types that underpin this deviant behavior are still largely unknown.… read more here.
Keywords: parvalbumin interneurons; isolation; mice; social isolation ... See more keywords
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.65215
Abstract: The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling. Fast-spiking GABAergic interneurons expressing parvalbumin (PV+) have a high mitochondrial content reflecting their large energy utilization.… read more here.
Keywords: dynamics parvalbumin; dependent mitochondrial; parvalbumin interneurons; miro1 dependent ... See more keywords