Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14813-z
Abstract: Individuals with autism spectrum disorder (ASD) have social interaction deficits and difficulty filtering information. Inhibitory interneurons filter information at pyramidal neurons of the anterior cingulate cortex (ACC), an integration hub for higher-order thalamic inputs important… read more here.
Keywords: inhibitory circuits; inhibitory; anterior cingulate; parvalbumin neurons ... See more keywords
Basal forebrain parvalbumin neurons modulate vigilant attention and rescue deficits produced by sleep deprivation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of sleep research"
DOI: 10.1111/jsr.13919
Abstract: Attention is impaired in many neuropsychiatric disorders, as well as by sleep disruption, leading to decreased workplace productivity and increased risk of accidents. Thus, understanding the neural substrates is important. Here we test the hypothesis… read more here.
Keywords: sleep deprivation; parvalbumin neurons; attention; forebrain parvalbumin ... See more keywords
Parvalbumin Neurons in Zona Incerta Regulate Itch in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.843754
Abstract: Pain and itch are intricately entangled at both circuitry and behavioral levels. Emerging evidence indicates that parvalbumin (PV)-expressing neurons in zona incerta (ZI) are critical for promoting nocifensive behaviors. However, the role of these neurons… read more here.
Keywords: role neurons; neurons zona; zona incerta; itch ... See more keywords