Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior
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DOI: 10.1038/s41598-020-64066-5
Abstract: Inhibitory interneurons are essential for proper brain development and function. Dysfunction of interneurons is implicated in several neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability (ID). We have previously shown that Arid1b haploinsufficiency… read more here.
Keywords: asd like; parvalbumin somatostatin; arid1b haploinsufficiency; haploinsufficiency ... See more keywords
Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons
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DOI: 10.1038/s41598-020-74385-2
Abstract: GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We… read more here.
Keywords: adult born; dentate granule; born dentate; parvalbumin somatostatin ... See more keywords