Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
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DOI: 10.7554/elife.71420
Abstract: The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as… read more here.
Keywords: parylated nucleosome; structure; remodeler alc1; alc1 ... See more keywords