A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22915
Abstract: Increased levels of reactive oxygen and nitrogen species play an important role in the development and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. The overproduction of these highly reactive chemical species leads… read more here.
Keywords: bos; mechanism neuroprotective; parylation; effect ... See more keywords
Impact of Asp/Glu-ADP-ribosylation on protein-protein interaction and protein function.
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202200083
Abstract: PARylation plays critical roles in regulating multiple cellular processes such as DNA damage response and repair, transcription, RNA processing, and stress response. More than 300 human proteins have been found to be modified by PARylation… read more here.
Keywords: interaction; protein protein; asp glu; parylation ... See more keywords
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109695
Abstract: The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic. Here, we report that PARP1 is an intrinsic driver for oligodendroglial development and myelination. Genetic PARP1… read more here.
Keywords: parp1 mediated; myelination; parylation; differentiation ... See more keywords
Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.02.002
Abstract: Poly(ADP-ribose) (PAR) is a nucleic acid-like protein modification that can seed the formation of microscopically visible cellular compartments that lack enveloping membranes, recently termed biomolecular condensates. These PAR-mediated condensates are linked to cancer, viral infection,… read more here.
Keywords: ribose dynamic; poly adp; parylation; formation ... See more keywords
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-20998-8
Abstract: Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the clinic for treatment of ovarian and breast cancer. Recently, histone PARylation… read more here.
Keywords: histone parylation; parylation; parylation factor; cancer ... See more keywords
Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1360
Abstract: Poly(ADP-ribosylation) (PARylation) is a reversible post-translational protein modification that regulates a number of cellular processes. It is generated by a family of PAR polymerases (PARP), of which PARP1 has recently been exploited as a target… read more here.
Keywords: novel parylation; identify novel; biosensor; parylation targets ... See more keywords
Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct269
Abstract: Background AZD5305 is a selective PARP1 inhibitor (PARPi) generated for improved therapeutic index compared with non-selective PARPi. Measurement of PARylation inhibition has been used to determine the pharmacodynamics (PD) of PARPi in clinical trials, but… read more here.
Keywords: inhibition; parylation inhibition; parylation; highly sensitive ... See more keywords
PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12010183
Abstract: Transcription is a multistep, tightly regulated process. During transcription initiation, promoter recognition and pre-initiation complex (PIC) formation take place, in which dynamic recruitment or exchange of transcription activators occur. The precise coordination of the recruitment… read more here.
Keywords: transcription insights; transcription; parylation; insights fine ... See more keywords
PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020394
Abstract: Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response by sensing DNA damage and docking DNA repair proteins on the damaged DNA site through a type of posttranslational modification, poly (ADP-Ribosyl)ation… read more here.
Keywords: parp inhibitors; inhibitors therapeutics; parylation; parylation parp ... See more keywords
A Double-Edged Sword: The Two Faces of PARylation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179826
Abstract: Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally,… read more here.
Keywords: dna repair; role parylation; parylation; double edged ... See more keywords