Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
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DOI: 10.1038/s41467-021-20998-8
Abstract: Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the clinic for treatment of ovarian and breast cancer. Recently, histone PARylation… read more here.
Keywords: histone parylation; parylation; parylation factor; cancer ... See more keywords